Uni-Logo
Sie sind hier: Startseite Arbeitsgruppen AG Leemhuis Signaling networks of receptor-systems targeting Rho GTPases control neuronal development
Artikelaktionen

Signaling networks of receptor-systems targeting Rho GTPases control neuronal development

The members of the Rho-family Rac, RhoA and Cdc42 are key regulators of many cellular processes during neural development. Often, one Rho-GTPase mediates different cellular effects by embedding in different effector-domain-complexes. The selection of these pathways could be achieved by selectively engaging different guanine nucleotide-exchange factors (GEFs.) How receptor-activated GEFs preferentially couple to different downstream effector pathways remains to be determined.

The aim of the project is to characterize the signaling networks of receptor-systems, the lipoprotein receptors Apoer2 and Vldlr, the peptidergic VPAC1/2 and PAC1 receptors and the glutamatergic NMDA receptors. They all target, beside other Rho GTPases, Cdc42 and are involved in the regulation of neurite motility. We want to identify and characterize the Cdc42-GEF-effector complexes being responsible for the different cellular events during the development of the neocortex.

Participants

Benutzerspezifische Werkzeuge