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AG Leemhuis

(Dept. Pharmakology II)


Note: This group does not exist any more.
Dr. Jost Leemhuis has left the university in April 2012


Areas of Research


selected publications within the last 5 years

Leemhuis J, Bouché E, Frotscher M, Henle F, Hein L, Herz J, Meyer DK, Pichler M, Roth G, Schwan C, Bock HH:
Reelin signals through Apoer2 and Cdc42 to increase growth cone motility and filopodia formation J Neurosci., J Neurosci. 30:14759-72, 2010

Gilsbach R, Schneider J, Lother A, Schickinger S, Leemhuis J, Hein L.:
Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis inmice at baseline but not after chronic pressure overload. Cardiovasc Res. 86, 432-42, 2010

Gilsbach R, Röser C, Beetz N, Brede M, Hadamek K, Haubold M, Leemhuis J,Philipp M, Schneider J, Urbanski M, Szabo B, Weinshenker D, Hein L.:
Geneticdissection of alpha2-adrenoceptor functions in adrenergic versus nonadrenergiccells. Mol Pharmacol. 75, 1160-70, 2009

Riegert C.,Rothmaier A.K., Leemhuis J., Sexton T.J., Neumaier J.F., Cassel J.C. and Jackisch R.:
Increased expression of 5-HT1B receptors by Herpes simplex virus gene transfer in septal neurons: new in-vitro and in-vivo models to study 5- HT1B receptor function. Brain Res Bull. 1;76, 439-53, 2008

Leemhuis J., Henle F. and D.K. Meyer.:
VIP induces the elongation of dendrites and axons in cultured hippocampal neurons: role of microtubules. Peptides. 9, 1700-5, 2007

Birthelmer A., Ehret A., Riegert C., Rothmaier A.K., Leemhuis J. and Jackisch R.:
Modulation of electrically evoked serotonin release in cultured rat raphe neurons. J Neurochem. 100,6: 1613-25, 2007

Henle F.*, Leemhuis J.*, Fischer C., Bock H.H., Lindemeyer K., Feuerstein T.J. and Meyer D.K.:
Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal Neurons. J Pharmacol Exp Ther. 319, 181-91, 2006 (* equal contribution)

Henle F., Fischer C., Meyer D.K. and Leemhuis J.:
VIP and PACAP38 facilitate NMDA-induced Dendrite Formation by Modifying the Activities of Rho GTPases and Phosphoinositide 3-Kinases. J Biol Chem. 281, 24955-69, 2006

Lindemeyer K., Leemhuis J., Löffler S., Grass N., Nörenberg W. and Meyer D.K.:
Metabotropic Glutamate Receptors Modulate the NMDA- and AMPA-Induced Gene Expression in Neocortical Neurons. Cereb Cortex. 16 1662-77, 2006

Meyer D.K., Fischer C., Becker U., Gottsching I., Boutillier S., Baermann C., Schmidt G., Klugbauer N., Leemhuis J.:
Pituitary adenylyl cyclase-activating polypeptide 38 reduces astroglial proliferation by inhibiting the GTPase RhoA. J Biol Chem. 280, 25258-66, 2005

Book chapters:

In: Tonner, Hein: Pharmakologie in Anästhesie und Intensivmedizin, Springer 1. Auflage 2010 Leemhuis J. Antibiotika, Grundlagenkapitel

In: Tonner, Hein: Pharmakologie in Anästhesie und Intensivmedizin, Springer 1. Auflage 2010 Leemhuis J., Kern W., deWith K. Anwendung von Antibiotika


CV of Priv. Doz. Dr. med Jost Leemhuis

Born August, 1969 in Düsseldorf, Germany
Nationality German
Social status married, 1 child
1990 - 1997 Medical School, University of Düsseldorf, Germany
1998 Graduation Dr. med., University of Düsseldorf, Germany
2007 Venia legendi, Pharmacology, University of Freiburg
2008 Medical specialist, Pharmacology
Scientific education and appointments
1997 Clinical Research Fellow, GlaxoWellcome, Hamburg
1998 - 1999 Neuropediatric Clinic, University Essen (Prof. Voit); medical scientist
2000 - 2007 Postdoctoral Fellow, Pharmacology (Prof. Aktories)
2008 visiting scientist, Yale Medical school (Prof. Strittmatter)
2008 –present Akademischer Rat, Pharmacology (Prof. Hein)
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